We identified 17 genes enriched in the p53 signaling pathway (Supplementary Table S4-5) to construct a heatmap (Figure 5D) and used qPCR to confirm the expression levels of these genes, including the downregulated genesCCND1,RRM2 andCDK6 and the upregulated genesDDB2,TP53I3,BAX,PERP,SESN1 andBBC3, in si-070974- and si-YBX1-treated NSCLC cells (Figure 5E). Here, RRM2 is linked to non-small cell lung carcinoma.