High albumin gradient (SAAG greater than or equal to 1.1 g/dL) is obtainable in the following conditions: heart failure, constrictive pericarditis, alcoholic hepatitis, cirrhosis, Budd-Chiari syndrome, portal vein thrombosis, idiopathic portal fibrosis, and massive hepatic metastasis. The gene discussed is ALB; the disease is constrictive pericarditis.