PRSS1 and hereditary chronic pancreatitis: Several different hereditary syndromes have been implicated in PDAC, including Hereditary Breast and Ovarian Cancer (BRCA1/BRCA2), Familial Atypical Multiple Mole Melanoma (CDKN2A), Ataxia-Telangiectasia (ATM), Hereditary Pancreatitis (PRSS1/SPINK1), Peutz-Jeghers syndrome (STK11/LKB1), and Lynch syndrome (MLH1/PMS2/MSH2/MSH6) [6-8].