,17 In addition to IL-1β, other inflammatory targets have been explored in earlier-phase clinical studies in DKD, including IL-6, nuclear factor erythroid 2-related factor 2, apoptosis signal-regulating kinase 1, Janus kinase 1/2, and chemokine (C-C motif) receptors 2/5.15 This evidence concerns the gene IL6 and diabetic kidney disease.