This prevention of renal disease progression was, furthermore, associated with a significantly reduced eosinophil percentage of leukocytes (−52%, P = 0.0293), a known consequence of IL-33 blockage (Supplementary Figure S6).47, 48, 49 Body weight, blood glucose, hemoglobin A1c, and urine volume were not affected by anti-ST2 treatment (Supplementary Figure S7). This evidence concerns the gene IL33 and kidney disorder.