In this patient, the presence of dry mouth and eyes, dental caries, anti-nuclear antibody (+), anti-SSA antibody (+), anti-Ro-52 antibody (+), along with a Schirmer Test ≤ 5 mm/5 min and a reduced natural saliva flow rate ≤ 0.1 mL/min, aligns with the 2016 the American College of Rheumatology and the European League Against Rheumatism Classification Criteria for Primary SS (15), confirming the diagnosis of SS. The gene discussed is CALR; the disease is synovial sarcoma.