STAT3 and neoplasm: Anomalously activated STAT3 promotes uncontrolled tumor cell growth and survival by a number of ways, including increased production of oncogenes like Myc proto-oncogene protein (c-myc) and cyclin D, as well as anti-apoptotic proteins like B-cell lymphoma-extra large (Bcl-XL) and Myeloid cell leukemia 1 (MCL-1) (62, 63).