The main intestine‐related diseases, including colon cancer, colorectal cancer (CRC), bleeding of the colon, rectal cancer, constipation, diarrhea, ileus, inflammatory bowel disease, and small intestine cancer (Supporting Information: Figure S1A), shared common genes such as STK11, CFTR, BMPR1A, SMAD4, NOTCH1, PKD1, MLH1, MSH2, APC, and MEFV (Supporting Information: Figure S1B) [6, 7, 8, 9, 10, 11]. This evidence concerns the gene SMAD4 and rectal cancer.