Elevated levels of ALAT andASAT are indicators of liver damage,28 whilealtered levels of urea and creatinine can indicate kidney failure.None of the values measured in bIF- or IF-pMHC-treated mice were significantlyelevated on any of the measured days compared to the PBS control.We found slightly elevated levels of ALAT and ASAT in all mice euthanizedon day 3 compared to day 8 and day 30, which we attribute to somehemolysis that occurred during blood processing (Figure 4a,b). Here, ABCB7 is linked to kidney failure.