CXCR1 and autoimmune disease: Additionally, AMD-3100 and 4-F benzoyl TN14003,which target the CXCR4 receptor, are useful in severe RA.118 Furthermore, drug molecules like reparixinand SCH-527123 inhibit CXCR1, which is another potential target.119 The dysregulation of chemokines is implicatedin RA as well as in similar autoimmune diseases and cancer.