In synovial fibroblast tissue, visfatin (PBEF)induces the release of inflammatory cytokines (IL-6, IL-1β,TNF-α) and matrix metalloproteases from synovial fibroblastsand chondrocytes, contributing to joint inflammation and degradationin RA patients.129 Resistin, expressedprimarily by macrophages, B cells, and plasma cells in the rheumatoidsynovium, correlates positively with inflammation markers like CRP,IL-1, and TNF-α. This evidence concerns the gene IL6 and rheumatoid arthritis.