Forexample, Decernotinib (VX-509) is a next-generation Jakinib undergoingphase II clinical trials and has demonstrated better selectivity forJAK3.99,100 Filgotinib is also a next-generation jakinibunder phase IIA trials that inhibits the expression of JAK1 and JAK2.101 Interstitial lung disease is a pulmonary complicationof RA. The gene discussed is JAK1; the disease is rheumatoid arthritis.