STAT1 and rheumatoid arthritis: It canalso induce inflammation by promoting T-cell survival and antibodyproduction while inhibiting the apoptosis of synovial fibroblasts.92,93 Different studies suggest that B-cell antigen receptor and CCR5may also activate the STAT1 which further stimulates synovial inflammationby inducing the expression of inflammatory genes.94 In contrast, there are some contradictory functions ofSTAT1, such as activation of apoptosis and growth arrest in variouscell types, suggesting a protective role in RA.