Not only the receptor but the levelsof ligands are also upregulated in the synovial joints of RA patients.RAGE overexpression is stimulated by cytokine factors such as IL-1βand IL-17 The severity of disease progression depends on a differentform of RAGE, as in the case of 82S polymorphic form that interactsmore strongly with its ligand and enhances the pro-inflammatory responsein RA patients.190 RAGE and its ligandcan be possible molecular targets in RA therapies. This evidence concerns the gene IL17A and rheumatoid arthritis.