Among these three subunits, IKK2 plays the most importantrole in RA inflammation.104 In RA, theactivation of specific subunits of NF-κB is observed, with p50and p65 being extensively studied, particularly in macrophages andsynovial fluid.105 NF-κB and relatedregulatory kinases may be potential targets to counteract the hyper-responsivenessin inflammatory cells. Here, NFKB1 is linked to rheumatoid arthritis.