MMP8 and rheumatoid arthritis: They contribute to cartilage deterioration and promoteangiogenesis in the affected joints.150,153 MMPs, includingMMP-1, MMP-2, MMP-3, MMP-8, and MMP-9, are produced by synovial lining,neutrophils, macrophages, and chondrocytes.154 MMP-1 and MMP-8 are key proteases directly associated with synovialjoint inflammation and bone erosion.154 Clinical studies are underway to investigate different MMP inhibitorsfor mitigating RA severity.