Notably, it is essential to highlight that while tumor metastatic lesions were apparent within the lungs of mice from the PBS group, Apilimod group, LNP-Blank group, and LNP@PTEN group in the bone metastasis model, no secondary organ metastases were discernible in the Apilimod + LNP@PTEN group (Figure 5B). Here, PTEN is linked to neoplasm.