Results from a systematic pharmacology study (Chen et al., 2018) suggest that XNJ might exert an anti-stroke effect by responding to oxidative stress, regulating blood pressure, calcium signaling pathways, and cell apoptosis among other biological processes and pathways, and Akt1, HIF1a, and ITGB2 may play key roles in the occurrence and regulation of stroke. This evidence concerns the gene ITGB2 and Stroke.