On the other hand, the expression of complement receptor 1 (CR1) and complement receptor 5a (C5AR1) was found to be downregulated in the B cells during sepsis (Figure 6F), while the levels of complement 3 ([C3], Figure 6E), B factor and complement 1 q ([C1q], Supplementary Figure S4B) appeared decrease in the in serum of patients suffering acute stage too. The gene discussed is CR1; the disease is Sepsis.