As anticipated, elevated levels of IL‐6 (NC: 28.97 ± 5.34 pg/mg tissue; Vehicle: 72.26 ± 10.01 pg/mg tissue), TNF‐α (NC: 19.83 ± 4.01 pg/mg tissue; Vehicle: 50.82 ± 5.85 pg/mg tissue) and MMP2 production (NC: 15.66 ± 3.02 pg/mg tissue; Vehicle: 53.26 ± 5.51 pg/mg tissue) were observed in the anterior vaginal walls of PFD rats (Figure 5A–C). This evidence concerns the gene MMP2 and polyostotic fibrous dysplasia.