To elucidate the mechanism underlying tumour suppression of TNKS‐mediated drug, A549 cells were treated with 9% NaCl (as a control group), Xiaoyan decoction, E7449 or Xiaoyan unit E7449 for 48 h, after which the proteins were harvested, the changes in the proteins were assessed via label‐free profiling. This evidence concerns the gene TNKS and neoplasm.