In this sense, inositol trisphosphate receptor (IP3R) andryanodine receptor (RyR) are two channels involved in calcium releaseby ER that are expressed in human neuroblastoma cells.26 IP3R is closely associated with mitochondriaas they form a complex with the chaperone glucose-regulated protein75 (GRP75) and voltage-dependent anion-selective channel 1 (VDAC1),one of the components of mPTP. The gene discussed is VDAC1; the disease is neuroblastoma.