The levels of Aβ42, Aβ42/40, total tau, p-tau, and miR-384 in NCAM+ EVs and NCAM/ABCA1 dual-labeled EVs from individuals with amnestic MCI and AD were significantly elevated compared to those in subjective cognitive decline, vascular dementia, and control groups [108]. The gene discussed is NCAM1; the disease is Alzheimer disease.