As mentioned, L1CAM has been used to isolate neuron-derived EVs since 2014, but in the MS field it was not used until 2021, when Pavan Bhargava and co-authors [44] used L1CAM and glutamate aspartate transporter (GLAST) to isolate putative neuron- and astrocyte-derived EVs, respectively, by immunoisolation from the plasma of MS patients. The gene discussed is L1CAM; the disease is myeloid sarcoma.