The DQA2, FGF5, IDI2 (for participants without diabetes), and MICB (for Europeans without diabetes) were positively associated with annualized eGFR slope change (represented decreased risk), while UMOD, HLA-E (without diabetes), NFATC1 (without diabetes), PFKFB2 (with diabetes), and YOD1 (with diabetes) were negatively associated with the slope change (represented increased risk), which were consistent with the principal findings. Here, PFKFB2 is linked to diabetes mellitus.