In addition, our SMR analysis with GTEx data for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) was also consistent with a longitudinal data analysis in American Indians, which reported that the variation in PFKFB2 appears to reduce PFKFB2 expression in adipose and kidney tissues and thereby increase the risk for adiposity and diabetic nephropathy. Here, PFKFB2 is linked to diabetic kidney disease.