For serologically defined colon cancer antigen 8 (SDCCAG8), recessive mutations in the SDCCAG8 gene can cause a nephronophthisis-related ciliopathy with Bardet-Biedl syndrome-like features [84], and SDCCAG8 appears to interact with APOL1 to modulate the risk for nondiabetic end-stage kidney disease [85]. This evidence concerns the gene SDCCAG8 and Bardet-Biedl syndrome.