A classical immunotherapy combination of a PD-1 inhibitor and a CTLA-4 inhibitor has been approved to treat a wide range of cancers, such as mesothelioma and non-small cell lung cancer (NSCLC), suggesting that dual or even multiple blockade of immune checkpoints have the potential to resolve the resistance mediated by the increased variety of checkpoints [14, 15]. The gene discussed is PDCD1; the disease is cancer.