CSF2 and neoplasm: During this differentiation process, immature neutrophils with a high degree of plasticity respond to high levels of IFN-γ and Granulocyte–macrophage colony-stimulating factor (GM-CSF) in tumor tissues by transforming into Programmed death-ligand 1 (PD-L1) heterotrimeric neutrophils, which severely inhibit T cell-mediated tumor immunity [16].