This approach disrupts the TME through Cr NPs laser-induced photothermal effects, enabling effective delivery of siYTHDF1 to TAMs to deplete YTHDF1 and inhibit STAT3 protein translation in an m6A-dependent manner, thereby shifting the STAT3-STAT1 equilibrium to enhance STAT1 expression, and achieving improvement of the TME and inhibition of tumor progression. This evidence concerns the gene STAT1 and neoplasm.