Studies have shown that the Ca2+/CaMKII pathway is activated in the bronchial epithelium of asthma patients CaMKII has been found to directly phosphorylate Beclin1 at Ser90, leading to enhanced K63 ubiquitination and activation of autophagy Importantly, we observed that Wnt5a-mediated autophagy and EMT were reduced when a CaMKII inhibitor was applied to block the Ca2+/CaMKII signaling pathway, indicating that Wnt5a relies on Ca2+/CaMKII to induce autophagy and activate EMT. This evidence concerns the gene BECN1 and asthma.