In the meantime, a significant decrease in average tumor weight (1.5 ± 0.21 g vs. 0.65 ± 0.14 g) and reduced cell proliferation, assessed by Ki67 IHC, were also observed in RACGAP1 knockdown xenograft (Fig. 4F and Fig. S4D). The gene discussed is RACGAP1; the disease is neoplasm.