MYC and neuroblastoma: All three neuroblastoma programs were strongly enriched for the classical cell line-derived adrenergic marker genes (Fig. 3a–c; 8.1 × 10−66 for Adrenergic I, P = 1.7 × 10−72 Adrenergic II, 1.1 × 10−23 for Neuroblastoma-MYC from one-sided Wilcoxon rank sum test, signature defined by Van Groningen et al. [10]), but consistent with a subset of previous studies [16, 17, 19], were not strongly enriched for mesenchymal markers.