MYCN and neuroblastoma: The adrenergic II pre-neuronal-like program was also observed in multiple other datasets (Fig. 4f and h) and the “neuroblastoma-MYC” (high-risk) program formed a dense hub (Fig. 4c), with similar programs recovered in high-risk (both MYC and MYCN overexpressing) tumors in all datasets (Fig. 4i).