TNF and primary biliary cholangitis: For example, KLRG1+ T-cell infiltration in liver samples from PBC patients is positively correlated with severe histologic hepatic inflammation and histologic hepatic fibrosis, while in peripheral blood (PB) samples, KLRG1+ T-cells contain substantially greater levels of cytotoxic molecules (such as granzyme B and perforin), inflammatory cytokines (IFN-γ and tumor necrosis factor α (TNF-α)), and inflammatory chemokine receptors than their KLRG1-negative counterparts [18].