Since KLRG1 inhibits mTOR signaling through the PI3K/AKT pathway, the lack of KLRG1 expression on TCRαβ+ CD4− CD8− double-negative T-cells in ALPS patients leads to overactivity of the mTOR pathway, resulting in abnormal lymphocyte proliferation [56]. This evidence concerns the gene KLRG1 and autoimmune lymphoproliferative syndrome.