KLRG1 mainly interacts with cadherin ligands expressed on the surfaces of cancer cells or APCs, subsequently recruiting tyrosine-protein phosphatases (Src homology 2-containing inositol phosphatase-1 (SHIP-1) and Src homology-2-containing protein tyrosine phosphatase 2 (SHP2)) following the phosphorylation of ITIM tyrosine residues within its cytoplasmic structural domain [44, 51]. Here, KLRG1 is linked to cancer.