In addition, in tumor-bearing mice, the migration of KLRG1+ NK cells to the bone marrow is impaired and regulated by C-X-C motif chemokine receptor 3, resulting in a rapid and selective decrease in the number of KLRG1− NK cells with potent effector functions in the bone marrow, which contributes to tumor escape from NK cell-mediated immune surveillance [124]. The gene discussed is CXCR3; the disease is neoplasm.