IL6 and respiratory system disorder: For other respiratory diseases, downregulation of IL6 signaling pathway presented a protective trend for bronchitis (ORIVW = 0.95, 95% CI = 0.87–1.05), pulmonary embolism (ORIVW = 0.90, 95% CI = 0.73–1.11), and lung cancer (ORIVW = 0.87, 95% CI = 0.73–1.04), but not for idiopathic pulmonary fibrosis (ORIVW = 1.27, 95% CI = 0.87–1.85).