Sex, age, race, high-density lipoprotein, alanine aminotransferase, asparate aminotransferase, albumin, bilirubin, alkaline phosphatase, serum calcium, serum 25(OH)D, phosphorus, eGFR, total cholesterol, diabetes, hypertension, vigorous work activity, gout, liver disease, kidney disease, history of fracture, thyroid disease, and removing both ovaries were included as covariates, we further evaluated whether BMI mediate the association between SUA and OP/osteopenia. The gene discussed is GPT; the disease is Osteopenia.