We use LASSO-Cox regression to screen for possible predictors, further multivariate Cox regression analysis showed coexisting arrhythmia, IMV usage and lower serum albumin values were significantly associated with lower survival probability of AECOPD patients for 7-day, 14-day and 21-day survival, and the model showed a good performance by assessed the C-index, AUC, and calibration plots. The gene discussed is ALB; the disease is cardiac arrhythmia.