The molecular imaging studies included in our review demonstrated that SV2A PET radiotracer binding as measured by [11C]UCB-J VT or BPND was significantly lower in several brain regions including the anterior cingulate cortex, hippocampus, occipital, temporal, parietal and frontal cortices, in individuals with chronic (3 out of 3 studies) and early-course (1 out of 2) schizophrenia relative to controls. This evidence concerns the gene SV2A and schizophrenia.