Increased expression of plasma soluble ACE2 was found in patients with cardiovascular diseases such as myocardial infarction, atrial fibrillation, valvular disease, and heart failure, reflecting a higher basal ACE2 expression and increased susceptibility in these conditions (García-Escobar et al. 2022; Silva et al. 2022). The gene discussed is ACE2; the disease is atrial fibrillation.