Second, our results also demonstrate that CTC analysis brings complementary information to ctDNA in almost 70% of the cases with some CTC ‘private’ mutations in genes implicated in immune evasion or tumor dissemination mechanisms like CTNNB1 (Karachaliou et al, 2022; Damsky et al, 2011; Spranger et al, 2015; Massi et al, 2017; Lin et al, 2020) and CDKN2A (Zeng et al, 2018). This evidence concerns the gene CDKN2A and neoplasm.