Age distribution was about the same in both groups at diagnosis (median age was 52 in the eLTS group and 55 in the MTS group) and did not differ significantly in gender (male gender in 58% of the eLTS and 54% of the MTS group) No significant differences in epigenetic GBM subclass—receptor tyrosine kinase (RTK) I, RTK II and mesenchymal (MES)—or in O6-methylguaninemethyltransferase (MGMT) promoter methylation status were found (Table 1, Supplementary Table 1). This evidence concerns the gene NTRK1 and glioblastoma.