Gsdmd−/− /Cdx2-Cre+ /ApcF/+ mice developed significantly fewer colorectal tumors compared to Gsdmd+/−/Cdx2-Cre+/ApcF/+ controls (Fig. 2a), demonstrating a previously unreported role of GSDMD in promoting sporadic CRC development. The gene discussed is CDX2; the disease is colorectal neoplasm.