Higher methylation levels in the cg47630224-MSH2 site were observed in the Australian hereditary BC cohort (mean Z-score patients = 1.971 vs −8.65E−8, p < 0.0001) and the Italian sporadic cases cohort (mean Z-score patients = 0.238 vs −0.016, p = 0.0057). Here, MSH2 is linked to breast cancer.