Breakages at concordant sites between bovine and human embryos were found on KCNMA1 and FHOD3 locus, which are both involved in nervous system development40,41, in FHIT, a fragile site found in somatic cells exposed to aphidicolin and in tumor cells31,42 and at DPP10, a long neuronal gene, and a hotspot of copy number variants43. The gene discussed is FHIT; the disease is neoplasm.