NDUFV1 and cancer: Mitochondrial complex I, the largest respiratory complex of the electron transport chain (ETC) and critical for OXPHOS13, as well as for mitochondrial calcium (Ca2+) homeostasis14, has been shown to enhance cancer aggressiveness and metastasis when specific subunits such as NDUFV1, NDUFA13, NDUFS3 or NDUFB9 are down-regulated or when its activity is inhibited by small molecules13.