Upon analyzing the expression of 11 model genes in prostate PRAD, we observed significant differential expression of eight genes (MYADM, MPDZ, LTBP2, DENND4C, PROK1, DDIT4, IGFBP3, and CFD) between normal and tumor tissues (Fig. 10A). The gene discussed is IGFBP3; the disease is prostate adenocarcinoma.