Flow cytometry gating on the malignant CD4+ PD-1high T cells showed their low dependence on glucose, and they were significantly more dependent on OXPHOS as compared to the CD4+ PD-1low cells in the AITL tumor, WT CD4+, CD8+, and CD19+ cells and tumor-infiltrating CD19+ and CD8+ cells (Fig. 2D). Here, CD4 is linked to neoplasm.