Tumor segments were significantly enriched for tumor-specific proteins (e.g., EPCAM, PARP1, EZH2), had higher proteomics-derived NE scores (Figure S5D), and showed upregulation of tumor-related pathways, e.g., DNA replication and repair (ATM, Fanconi, BARD1), tumor suppressors (RB1, E2F targets, P53 regulation), and Myc. This evidence concerns the gene RB1 and neoplasm.