Applying pan-cancer TME signatures,53 non-NE TME was marked by immune infiltration including natural killer (NK) cells, B cells, and M1 tumor-associated macrophages (TAM-M1) and upregulation of immune co-activators (CD40LG, CD80) (Figure 3B) compared with hybrid-NE and NE TME.9 The gene discussed is CD40LG; the disease is cancer.