Many studies have confirmed that HPV mainly combines with the tumor suppressors p53 and pRB through the E6 and E7 proteins to cause uncontrolled cell proliferation, resulting in damage or even loss of cellular DNA self-repair function, leading to cancer.7, 8, 9, 10 The characteristic of HPV E6 protein is that it has two structural domains, which contain zinc finger structures, and these zinc finger structures bind to DNA and RNA and mediate protein-protein interactions to realize the cell transformation of E6 protein.11 The gene discussed is TP53; the disease is cancer.