Elevated shear stress within LVAD pumps can lead to abnormal cleavage of von Willebrand factor (VWF) multimers resulting in the loss of larger multimers, a hemostatic disorder known as acquired von Willebrand Syndrome (AvWS).2,6 Acquired von Willebrand Syndrome induced by LVADs has been highlighted as a possible cause of bleeding events, while concurrently demonstrating a potential lower risk of ischemic events.7,8 Hence, routine measurements of the VWF profile may aid in risk assessment. The gene discussed is VWF; the disease is vascular hemostatic disease.