VWF and ischemic stroke: This disparity in results may be attributed to their comparison of patients with a ratio ≤0.8 against those above 0.8, whereas we used a cutoff of 0.7 according to the current guidelines.14 Values ≤0.7 are deemed abnormal, which may explain our observation of a higher GIB event rate among patients with a VWF:CB/Ag ratio ≤0.7 in comparison to Meyer et al. 14,18,31 In contrast, patients with a dip ≤0.7 in the VWF:Act/Ag ratio exhibited a reduced risk of ischemic stroke.