In patients with VWF:CB/Ag and VWF:Act/Ag ratios ≤0.7 significantly more gastrointestinal bleeding (hazard ratio [HR]: 2.53; 95% CI = 1.1–5.8, and HR: 3.7; 95% CI = 1.5–9.2, respectively) and hemorrhagic stroke events (HR: 3.5; 95% CI = 1.6–7.6 and HR: 4.9; 95% CI = 2.1–11.7, respectively) were observed throughout the entire late (>60 days) postoperative period. Here, VWF is linked to hemorrhagic stroke.