reported that EV‐mediated delivery of macrophage migration inhibitory factors contributed to temozolomide resistance in gliomas by downregulating the tissue inhibitor of metalloproteinase 3 and activating the PI3K/Akt signaling pathway.[41] In light of these findings, we focused on the role of specific protein cargos in Rg1‐EVs. Here, AKT1 is linked to central nervous system cancer.