CD8A and neoplasm: In the future, it will be interesting to analyze immune cells from other parts (i.e., stroma and TLS) by modifying the tissue processing method to splice the immune landscape of the whole tumor tissue, and furthermore, to elucidate the subtype and molecular features of parenchyma infiltrating CD8+ T cells by co‐culturing the pLCO model with peripheral blood or tumor infiltrating lymphocytes, therefore constructing more sophisticate 3D structures representing the stromal tissue in order to recurrence the in vivo anti‐tumor immunity of patients.