ZIC1 and neoplasm: For example, the TPBG and GPR31 genes are highly correlated with the HCs‐TME subset and have known associations with tumor cell migration, proliferation, and recurrence via EMT.[20]PCP4, specific for the LCs‐TME subset, is a potential therapeutic target as it inhibits EMT and promotes apoptotic cell death.[21] In addition, ZIC1, which is frequently inactivated by promoter hypermethylation, acts as a tumor suppressor by modulating PI3K/Akt and MAPK pathways and influencing EMT in several cancers, including thyroid, breast, and gastric cancers.[22]