To explore the correlation between tumor spatial heterogeneity patterns and the previously established molecular subtypes (SCLC‐A, SCLC‐N, SCLC‐P, and SCLC‐Y) of SCLC defined by RNA‐seq, we extracted the spatial expression of four key transcription regulators (ASCL1, NEUROD1, YAP1 and POU2F3) as previously described by Rudin et al.[10] to assess SCLC molecular subtypes across 79 ROIs in 25 patients. The gene discussed is NEUROD1; the disease is small cell lung carcinoma.