Consistent with this, the RT-qPCR results showed that i-PRFe or PRFe with OM could noticeably upregulate the mRNA expression levels of four odontogenic genes compared with the OM group after induction for 14 and 21 days, and the relative expression of ALP , DSPP and OCN in the i-PRFe with OM group was much higher than in the PRFe with OM group on day 21 ( P <.05, Figure 5C). Here, DSPP is linked to ocular melanoma.