Here, we observed higher TLR2, TLR4, TLR5, TLR6, TLR8, TLR9, Myd88, NLRP3, ASC, and TNF-α mRNA expression at seven weeks after infection by S. mansoni in BALB/c and C57BL/6 mice compared to Swiss mice. The gene discussed is TLR4; the disease is infection.