These patterns suggest that after recruited lung monocytes diverge toward either SPP1-Mφ or FOLR2-Mφ states, IPF macrophages from either population may converge into a common profibrotic SPP1-Mφ archetype, although this should be interpreted within the constraints of pseudotime analysis, which cannot distinguish bona fide phenotypic transitions from phenotypic similarities. The gene discussed is SPP1; the disease is idiopathic pulmonary fibrosis.