While there is ample evidence that PPM1D is an oncogenic driver in many types of cancers (Ali et al., 2012; Khadka et al., 2022; Li et al., 2002; Nguyen et al., 2010; Wu et al., 2016), the clinical importance of targeting pre-malignant PPM1D-associated clonal expansion in the hematopoietic system is not clear. This evidence concerns the gene PPM1D and cancer.