In contrast, ALS due to ANXA11 p.G38R and c.1086 + 1G > A has been associated with annexin A11 aggregates in the form of NCIs, DNs and skein-like inclusions which comingle with TDP-43 aggregates in cortical, hippocampal, subcortical and spinal cord neurons [23, 26]. Here, ANXA11 is linked to amyotrophic lateral sclerosis.