Given that ANXA11 variants have been associated with a dual TDP-43 proteinopathy and annexinopathy, and because these two cases were clinically and neuropathologically diagnosed with progressive supranuclear palsy, a tauopathy, this suggested that these two variants may not play a significant role in TDP-43 proteinopathy. The gene discussed is ANXA11; the disease is Classical progressive supranuclear palsy.