ANXA11 and amyotrophic lateral sclerosis: In the FTLD–TDP case with a secondary clinical diagnosis of ALS (Table 2, case #4), annexin A11 aggregates were confined to both upper and lower motor neurons, and amygdala and hippocampus, while TDP-43 pathology was more widespread and included other frontal and temporal lobe, striatum and thalamus, and substantia nigra and medulla areas.