Luminal A subtype expresses ER and PR; luminal B subtype is ER+ , PR ± with a high expression of Ki67; Her2 subtype is Her2 + , and a high expression of Ki67; and triple negative breast cancer (TNBC) subtype is ER−, PR−, Her2− and a high expression of Ki67 [6]. This evidence concerns the gene ESR1 and triple-negative breast carcinoma.