TARDBP and amyotrophic lateral sclerosis: Participants with ALS/FTLD-TDP had on average the youngest age at death (mean 72 years), participants with LATE-NC had the highest average age at death (mean 84 years), the TDP-43 Other group also tended to be a bit older (mean 81 years), compared to those with No TDP-43 (mean 79 years).