The LATE-NC group had the highest rate of phospho-specific TDP-43 antibody use, indicating that the phospho-specific antibody may be more sensitive to the potentially subtle TDP-43 inclusions in LATE-NC and thus LATE-NC was detected more often when this test was used, whereas this was not the case for ALS/FTLD-TDP where TDP-43 inclusions are usually more widespread. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.