Our results for the diverging patterns of associations for ALS/FTLD-TDP and LATE-NC in relation to participant characteristics, clinical diagnoses, and co-occurring pathologies, are largely in agreement with a previous study using NACC data where they included participants with TDP-43 presence and identified different clusters of participants using measures of global cognition, PPA, bvFTD, and neuropsychological assessment, along with age at death [41]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.