Additionally, in the aforementioned age-based examinations of ALS-TDP [58] and genetically-confirmed FTLD-TDP [18] the authors found that in older ALS/FTLD-TDP participants the distribution of TDP-43 was more heavily limbic and thus resembling LATE-NC more than when found at younger ages. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.