Those with both ALS-TDP and FTLD-TDP tended to have the most widespread inclusions (98% had TDP-43 in all regions), those with FTLD-TDP alone also tended to have extensive TDP-43 inclusions (77% TDP-43 in all regions), while those with ALS-TDP alone had more isolated TDP-43 (Supplementary Fig. 7). Here, TARDBP is linked to amyotrophic lateral sclerosis.