Participants with ALS/FTLD-TDP (Fig. 4a) generally had TDP-43 inclusions across all the assessed brain regions (78%), with the EC/ITC being the single most common region (95%) followed by the hippocampus (91%), neocortex (89%) and amygdala (88%). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.