TARDBP and amyotrophic lateral sclerosis: By restricting the sample analyzed to those with all TDP-43 related pathology information available, we were able to examine not only the frequency of ALS-TDP, FTLD-TDP, and LATE-NC in NACC more precisely, as missing regional assessments can result in some degree of misclassification, but we were also able to examine the regional patterns of TDP-43 deposition across these different pathological conditions.