Specifically, there could be considerable variability in the EC/ITC due to ambiguity of which region (EC or ITC) is assessed, and in the “neocortical” TDP-43 assessment depending on whether the middle frontal gyrus (relevant to LATE-NC and FTLD-TDP) or the motor cortex (more relevant to ALS-TDP) were sampled. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.