Notably, while a large proportion of participants (3058, 71%) had at least one regional TDP-43, FTLD-TDP, ALS, and HS-A assessments available, a significant proportion only had ALS and HS-A assessments (654, 15%, likely due to the considerations mentioned above relating to not requiring a TDP-43 stain for these measures) or were only missing a regional TDP-43 assessment (206, 5%) or ALS assessment (202, 5%). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.