With the growing recognition of the importance of pathological TDP-43 to dementia and with more widespread routine assessment of TDP-43 at neuropathology centers, the National Alzheimer’s Coordinating Center (NACC) included assessment of TDP-43 in the neuropathology version 10 form (v10) [12, 54] used by the national Alzheimer’s Disease Centers (ADCs) since 2014. The gene discussed is TARDBP; the disease is dementia.